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Nevertheless, the level of biological activity is influenced by concentration and how they are activated and deactivated inside the body

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*Correspondence: Marc Diederich, College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, South Korea e-mail: [email protected] Michael Schnekenburger, Tommy Karius, and Marc Diederich have contributed equally to this work

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doi: 10.1007/s12011-009-8542-3 18 CollaG.NardiS.CardarelliM.ErtaniA.LuciniL.CanaguierR.et al

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Standard chemotherapy using 5-FU often suffers from poor therapeutic response, systemic toxicity, limited drug absorption, low tumor specificity, and resistance

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